NICU Copilot

Neonatal Sepsis Workup

Early (<72h) vs late-onset. Low threshold for empiric antibiotics in unstable neonate.

Educational decision support · Not a medical device · Do not enter PHI

All references

Key points

EOS: ampicillin + gentamicin. LOS: vancomycin + gentamicin (or per unit antibiogram).
CBC, CRP, blood culture; LP if meningitis suspected and stable.
Reassess at 36–48h based on cultures and clinical course.

Pitfalls

Negative blood culture does not rule out sepsis in clinically ill neonate.
Avoid prolonged empiric antibiotics — increases NEC and mortality risk.

Ask the Copilot

— EOS risk calculator?
— When to stop empiric antibiotics?

Important Notice

Please read before continuing

The Baby Copilot is an educational and informational clinical reasoning support tool intended for licensed healthcare professionals and trainees. It is not a medical device and is not intended to diagnose, treat, cure, prevent, or manage any patient condition.

Outputs generated by The Baby Copilot are AI-generated educational suggestions based on user-provided information and may be incomplete, inaccurate, or inappropriate for a specific clinical situation. All clinical decisions remain solely the responsibility of the treating healthcare professional.

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The Baby Copilot does not replace clinical judgment.
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