NICU Copilot

Bilirubin Thresholds

Phototherapy & exchange transfusion guidance.

Neurotoxicity risk factors
Risk factors: GA <38 wk, albumin <3.0 g/dL, isoimmune hemolytic disease, G6PD deficiency, other hemolytic disease, sepsis, or significant clinical instability in the previous 24 h.
Phototherapy threshold
17.1 mg/dL
GA 38w, 48h, no risk factors
Exchange threshold
22.1 mg/dL
≈ phototherapy + 5 mg/dL

Educational estimate based on the AAP 2022 hyperbilirubinemia guideline (Kemper et al., Pediatrics 2022) and the Maisels 2012 preterm consensus. Always confirm against the official nomogram and your unit's protocol before clinical action. Direct hyperbilirubinemia is always pathologic and requires separate workup.

Important Notice

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The Baby Copilot is an educational and informational clinical reasoning support tool intended for licensed healthcare professionals and trainees. It is not a medical device and is not intended to diagnose, treat, cure, prevent, or manage any patient condition.

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